OpenEvidence: Expanding the world’s collective medical knowledge

Doctors today are stretched to the breaking point. The US is on track to be short 100,000+ doctors by 2030. Burnout remains stubbornly high, and the volume of medical knowledge published annually doubles every five years, making it impossible to stay up to date with the latest and greatest medical information.

Enter OpenEvidence: a physician-only AI search platform built from the ground up for medicine. Within seconds, OE distills insights from tens of millions of peer-reviewed studies, drawing on content partnerships with the American Medical Association, The New England Journal of Medicine, JAMA, and all 11 JAMA specialty journals, and returns concise answers anchored in citations, never speculation. Whether it’s “Which second-line therapy best fits a diabetic patient with CKD and heart failure?”, or the latest oncology trial, clinicians see the freshest evidence right at the point of care.

Word of mouth has propelled OpenEvidence into more than 10,000 hospitals and clinics, helping healthcare providers access, evaluate, and apply the world’s medical knowledge. This year alone, more than 100 million Americans will be treated by a physician who has used OpenEvidence.

Daniel Nadler, Zachary Ziegler, and their world-class team are building a second brain for medicine: one that empowers every clinician to deliver safer, smarter care. We’re honored to join them on this mission and to help accelerate the day when every patient decision is guided by the best evidence the moment it matters.

— Mamoon, John, Josh, Nadia